Журнал клинических и экспериментальных дерматологических исследований
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Challenging Approach with Nanoformulation and Photodynamic Therapy in Dermatology

Fu-Tang Pan, Wei-Zhi Wu, Qiao-Gui Zhi and Qi-Xing Liang

Background:Photodynamic therapy (PDT) and holds substantial promise in improving outcomes of patients with a form of cutaneous conditions and dermatological conditions such as keratosis and basal cell carcinoma, etc. Use of 5-aminolevulinic acid (ALA) was sanctioned as secure and effective for use as a treatment.

Methods:In our work, we used Photodynamic therapy in patients with selected skin cancerization, and evaluated the fluorescence from photo sensitizer to constitute the field cancerization, which helps in analyzing the efficacy of the technique.

Results:From our study, it is clear that use of ALA with PDT against different skin cancerization has significant effects. However, the effect of efficacy varied according to the type of carcinoma. In our study, we observed that nano- ALA with PDT targeted about 70-80% more skin lesion and the mean reduction area of skin cancerization was about 10% greater with nano-ALA and PDT.

Conclusion:Our findings suggest use of ALA-PDT as a simple, cost effective, and novel method that can be used for various skin cancerization treatments.