Анестезия и клинические исследования
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ISSN: 2155-6148
ISSN: 2155-6148
Mudgalkar Nikhil N
Introduction: The incidence of Postoperative nausea and vomiting (PONV) associated with laparoscopy is very high. With increase in day care surgeries as well as laprascopic techniques, the problem of PONV has grown bigger.There are many classes of drugs,there are very less studies where combination therapy was used . So we intend to try combination therapy with ondensetron and dexamethasone for this problem and compare it with only ondensetron .
Materials and Methods: In this randomized, parallel group and Non crossover clinical trial, we studied 50 ASA grade I and II patients of age group 20-45 years undergoing elective laparoscopic surgeries under general anaesthesia.those who met with inclusion criterion, patients were randomized to receive injection ondensetron 4 miligram Intravenous and injection ondensetron 4 miligram and injection dexamethasone 8 miligram .Demographic variables were compared.The incidence of Nausea, vomiting as well as any untoward side effects were compared in both the groups.
Results: A total 50 patients were enrolled in the study. They were randomized in Group A (ondensetron) verses Group B (ondensetron and dexamethasone).Demographic variables were comparable in both the groups. The incidence of nausea was 52% in ondensetron group while it was 20 %in combination group. The incidence of vomiting also was significantly less in combination group with 12%participants experiencing vomiting in Group A while 8%in Group B.There were no side effect observed in any patients related to study medication.
Conclusion: ondansetron and dexamethasone given intravenously just after intubation is safe and more effective than intravenous ondansetron alone in nausea and vomiting in patients undergoing elective laparoscopic surgeries under general anesthesia.