Журнал лекарственного метаболизма и токсикологии
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ISSN: 2157-7609
ISSN: 2157-7609
Necati Ozok and Ismail Celik
The present study was aimed to investigate the effects of some synthetic plant growth regulators; ß-Naphthoxy acetic acid (ß-NOA) and 4-Chlorophenoxy acetic acid (4-CPA) at 10 and 20 ppm dosages on liver damage, antioxidant defense system and lipid peroxidation in rats. Rats were divided into 12 groups as control, ß-NOA and 4-CPA at 10 and 20 ppm dosages application groups. Serum marker enzymes and biochemical parameters were selected as biomarkers for liver damage. Antioxidant defense systems as SOD, GR, CAT, GSH-Px, GST and G6PD enzyme activities and GSH and MDA contents were determined in tissues as the indicators of oxidative stress. At the end of experiments, the statistically significant changes were observed in the levels of TPRO, TALB, TCHOL, TBIL, AST, ALT and LDH as liver damage serum biomarkers in rats exposed to 10 and 20 ppm of ß-NOA and 4-CPA as compared with controls. MDA levels increased in all the tissues of rats exposed to ß-NOA and 4-CPA dosages whereas the fluctuation in SOD, GR, CAT, GSH-Px, GST and G6PD enzyme activities and GSH levels were observed compared with controls. It could be concluded that the treatments of ß-NOA and 4-CPA dosages may induce liver damage and oxidative stress.