Журнал продуктов питания: микробиология, безопасность и гигиена
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Fecal Short-Chain Fatty Acids: Associated with Gut Inflammation among Children of under Five at Hawassa, Sidama Regional State, Ethiopia

Berhanu Kibemo Lefebo, Dejene Hailu Kassa, Baye Gelaw Tarekegn

Inflammatory Bowel Disease (IBD) in children is becoming more prevalent globally. According to epidemiology studies, it affects many children who live in poor sanitation and unhygienic environments. According to earlier research done on an animal model and in the human population, SCFAs have been linked to gut inflammation biomarkers. However, studies on the association of gut inflammation with SCFAs were scarce in Ethiopia. Thus, the purpose of this study was to assess the relationship between fecal SCFAs and gut inflammation in Hawassa City, Sidama Region, Ethiopia. A community-based cross-sectional study design was employed, and 82 children were included. A simple random sampling technique was used to select children from the source population. Independent samples-t-test, factorial ANOVA, and linear multiple regression were used to analyze data. The mean (± SD) of total SCFAs was 1.57 (± 0.16) μmoles/g stool sample. Gut inflammation was strongly and negatively correlated with total fecal SCFAs (r=-0.58, p