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Multifunctional Ingredient Dietary Supplement for Management of Hyperglycemic and Hypercholesterolemic Therapy of Diabetes

Pawar K and Thompkinson DK

A dietary supplement with multifunctional ingredients was designed, formulated and optimized using Response Surface Methodology. To evaluate the hypoglycemic and hypocholesterolemic efficacy of dietary supplement an invivo studies were conducted for 8 weeks. A total of thirty rats was taken and allocated to five groups with 6 rats each, First group (Group I) was given 100 percent control diet, second group (Group II) was fed with 20 percent commercial diabetic supplements while the other three experimental groups (III, IV and V) were given formulated dietary supplement substituting with control diet at 10, 20 and 50 percent. In all groups diabetes was induced by intraperitoneally administration of streptozotocin. Body weight, Blood Glucose and Cholesterol were estimated during the experimental period. Among the various dietary groups, 50 percent dietary supplementation resulted in a reduction of 16.81 percent blood glucose, 33.94 percent blood plasma cholesterol and 4.16 percent increase in body weight.