Журнал клинических и экспериментальных дерматологических исследований
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Scleroderma Treatment by Using Laser

Parnia Wieser

Localized Scleroderma (LoS) occurs due to excessive deposition of the collagen on the skin. It is also known as Morphea includes a variety of autoimmune diseases of sclerosing skin. It is characterized by inflammation and localized skin thickening. However, in some cases, deeper organizations may also be involved. Although morphea is not considered a life-threatening illness, obvious cosmetic variants, functional or psychosocial disorders affect multiple areas of the patient's quality of life. Treatments for LoS are often inadequate for many treatments that are of limited efficacy or have serious side effects. Due to advances in laser use and their beneficial effects the purpose of this study is to reported use of lasers in morphea. The active phase of morphia represents limited inflammation manifested as red or purple spots, followed by characteristic porcelain white or waxy yellow curable plaques often subjective symptoms such as pruritus and pain. After months or years the sclerosing plaque disappears but atrophy and poor pigmentation of the skin and/or deeper tissue persists as an atrophic phase. Some severe types, especially the generalized linear type may be associated with a variety of extracutaneous symptoms. Diagnostic skin biopsy should be performed only when the clinical picture is unclear, but it should be emphasized that histopathological features reflect the stage. Early active lesions with thickened and homogenized collagen bundles and perivascular infiltration are usually composed of lymphocytes and plasma cells or eosinophils and monocytes. The epidermis is usually atrophic