Журнал клинических и экспериментальных дерматологических исследований
Открытый доступ
ISSN: 2155-9554
ISSN: 2155-9554
Sherief Mahdy Hussein*, Mohammed Abd el Hakim Sorour, Ahmed Hossain, Shaimaa Ahmed Abd el Azim, Ahmed Soliman, Hany Shehata, Noha Sami Hanafy
Vitiligo is an idiopathic disorder of skin and hair characterized by melanin loss. Nonetheless thyroid disorder is a major cause of this pathology, other factors participate in its expression. Hormones such as, testosterone and estrogen have been suspected as drivers of this disorder. The present study aimed to determine the levels of testosterone and estrogen in serum of vitiligo patients. The study included 30 patients with vitiligo lesions (18 males and 12 females; ages ranged from 28–40 years and 30 healthy volunteers as control group (17 males and 13 females; ages ranged from 25-40years). All patients of vitiligo were recruited from Medical research center of excellence of National Research Centre, Egypt, during a period of 4 months (August 2020 to November 2020). Average period of the disorder in vitiligo group was 5.0 years. Vitiligo diagnosis is done clinically and confirmed using Wood’s lamp.
Blood samples were taken from both the patient and control groups, testosterone and estrogen were assessed. Results: The present study declared a significant increase in the level of testosterone in males of VP compared to control, while significant increase in estrogen level in females of VP related to their corresponding control. Conclusion: some hormonal indicators have a role in pathogenesis of vitiligo where their disturbance leads to melanocyte destruction and/or depigmentation.