Анестезия и клинические исследования
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Study of Attenuation of Cardiovascular Response during Laryngoscopy and Intubation Using Two Different Doses of Pregabalin as Premedication in Controlled Hypertensive Patients-A RCT

Rajesh Meena, Kavita Meena and Shashi Prakash

Introduction: laryngoscopy and tracheal intubation are powerful noxious stimuli that should be attenuated.1 effect more severe in hypertensive patients.2 The present study evaluated the safe and clinically effective dose of oral pregabalin as premedication for attenuation of pressor response of airway instrumentation in controlled hypertensive patients.

Methods: After ethical committee clearance total of 90 controlled hypertensive adult consented patients aged 30-60 years(M/F),ASA grade II were included,and randomized into three groups of 30 patients each by computer generated random number tables. Group I received oral placebo, Group II oral pregabalin 75 mg HS+150 mg 1 h before surgery and Group III oral pregabalin 75 mg HS+300 mg 1 h prior to induction. Duration of study 2012-2013. Data was analysed using Chi-square, Anova and T test and statistical analysis was performed using SPSS, windows version 19.0. the power of the study from primary object is 80 %. Anaesthetic technique was standardized and all groups were assessed for pre‑operative sedation, haemodynamic changes after the premedication, before and after induction, after laryngoscopy and intubation.

Results: Pre‑operative sedation levels were higher with pregabalin premedication. Significant increase in heart rate and mean arterial pressure was observed in Groups I and II after airway instrumentation, while statistically significant attenuation of mean arterial pressure was seen in Group III. No significant decrease in heart rate was observed in any group.

Conclusion: Oral pregabalin as premedication adequately sedated the patients, attenuated haemodynamic pressor response in a dose‑related fashion.