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Study of Microsatellites Role in BRCA2 Gene Causing Pancreatic Cancer and Breast Cancer

Appa Rao Allam, Sridhar R Gumpeny, MN Vamsi Thalatam, S Sita Ram Babu, N Ravi Shankar, P Anuradha

BRCA2 gene plays an important role in the development of pancreatic cancer. Diabetics may have a slightly increased risk of pancreatic cancer. Previous literature reveals that the Mutations in these genes are also causing the breast cancer. A detailed bioinformatics study of all the known mutations in the BRCA2 gene revealed interesting information. The information of all the experimentally proven mutations were collected and analyzed using bioinformatics tools and software programs. We tried to find out whether the presence of microsatellites or simple sequence repeats in the BRCA2 gene has any significance in the generation of these mutations. Our analysis revealed that there are 161 mutations available (HGMD) in BRCA2 gene under missense/ nonsense Category. We report that none of these 161 mutations fall inside the microsatellite tracts and thus indicating no role of microsatellites in BRCA2 gene.