Журнал противовирусных и антиретровирусных препаратов
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A New Paradigm for Developing Antiviral Drugs Exemplified by the Development of Supremely High Anti-HIV Active EFdA

Hiroshi Ohrui

The fundamental concept for developing anti-viral modified nucleoside was proposed. An idea to use 4’-C-substituted-2’-deoxynucleoside derivatives based on the fundamental concept was also proposed to solve the problems of the existing highly active antiretroviral therapy (HAART).