Журнал разработки лекарств
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Development of novel methodologies for the synthesis of ind-2-enone and piperidine-2, 6-dione frameworks using Baylis-Hillman adducts

D V Lenin

The present day synthetic chemistry demands development of novel carboncarbon bond forming reactions based on the concept of environmental protection. Synthetic chemists have been working in this direction for the last several years. The Baylis-Hillman reaction is one such reaction developed in recent years, on the basis of concepts of atom economy and organo-catalysis that are most important components of environmental protection. Ind-2- en-1- one framework represents an important class of carbocyclic molecules because these derivatives are found in important natural products.