Журнал лекарственного метаболизма и токсикологии
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Disposition Kinetic of Amoxicillin in Healthy and Nephropathic Goats with Immunological and Residual Level in Blood and Tissues

Sanjib Khargharia, Animesh K. Chakraborty, Anjan Bhattacharyya and Tapan K. Mandal

In the present investigation, we evaluated disposition kinetics of amoxicillin in healthy as well as nephropathy black-Bengal goats of either sex through single intravenous (IV) route along with metabolism aspects in all vital organs and urine after repeated therapeutic (TP, 10 mg/kg) and one half of therapeutic dose (HTP, 5 mg/kg) consecutively for 60 days through intramuscular administration (IM), evaluation of blood biochemistry and liver cytochrome p₄₅₀ component. Higher C_lB, AUC and lower MRT values in nephropathic goats compared to healthy goats indicates rapid distribution and elimination of drug from plasma when amoxicillin was administered to goats with acute renal failure. Continuous administration through intramuscular route up to 60 days revealed biochemical, hematological, histopathological changes in therapeutics as well as below therapeutic dosage level in blackBengal goats. Present study also revealed immunosuppressive effect during 60 days continuous intramuscular administration and confirmed stimulatory effect on Cytochrome p₄₅₀ enzyme system.