Journal of Fertilization: In Vitro - IVF-Worldwide, Reproductive Medicine, Genetics & Stem Cell Biol
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Effect of post embryo transfer Vitamin C supplementation on the outcome of in-vitro fertilization

Reitu Patel, Raman Patel

Background: In-vitro fertilization is successful Assisted Reproductive Technology for infertility but it has challenges like recurrent implantation failure, miscarriages and premature birth. Supplementation of different micronutrients during In-vitro fertilization has emerged as upcoming modality to improve outcome.

Objective: To evaluate the effect of post embryo transfer supplementation with vitamin C on the outcome of the In-vitro fertilization.

Methodology: A randomized open-label study was carried out on 120 women undergoing In-vitro fertilization for infertility treatment. They were randomly divided in two groups; one group received 1000 mg/day oral Vitamin C supplementation post embryo transfer along with the standard treatment protocol of In-vitro fertilization and other group received standard treatment protocol for the In-vitro fertilization only. Both the groups were followed up till its outcome and compared statistically in terms of spotting, bleeding, hospitalization, term delivery and child birth weight.

Results: Increased intake of ascorbic acid significantly reduced spotting (81.67% in Vitamin C Group vs. 63.33% in Control Group; p=0.0245) and reduced need of hospitalization (p=0.032). Intake of Vitamin C significantly reduced the incidence of low child birth weight (46.67% in Vitamin C Group vs. 76.67% in Control Group; p=0.0007). Significant improvement in duration of pregnancy was achieved with intake of Vitamin C with Preterm pregnancy 20%, term pregnancy 65% and lower incidence of miscarriages 15% (p=0.0819). It was observed that the technique of In-vitro fertilization does not have significant impact on outcome of pregnancy in both the groups (p>0.05).

Conclusion: Vitamin C supplementation has significantly improved the outcome of In-vitro fertilization techniques with reduced incidence of spotting and miscarriages along with improved term pregnancy.