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Enhancement of Transdermal Delivery of Indomethacin and Tamoxifen by Far-Infrared Ray-Emitting Ceramic Material (BIOCERAMIC): A Pilot Study

Shoei Loong Lin, Wing Pong Chan, Cheuk-Sing Choy and Ting-Kai Leung

BIOCERAMIC have been found to modulate various biological effects. Our earlier published research on various cell lines demonstrated that BIOCERAMIC promoted microcirculation, upregulated calcium-dependent nitric oxide and calmodulin, and exerted an antioxidant effect by increasing hydrogen peroxide scavenging ability. The development of pain relief systems requires most possible minimum doses and methods for effective local control of pain, so as to protect liver and renal function. There is also clinical necessary to develop targeted delivery of estrogen inhibitor in the breast using a local drug release system, to protect the breast from the increased cancer risk associated with the use of estrogen therapy. We compared the viscosity of BIOCERAMIC irradiated water and control water, and found that BIOCERAMIC might weaken the hydrogen bonds. Such breaks are caused by the loss of hydrogen bond covalence resulting from electron rearrangement. The purposes of this study were thus to investigated a transdermal drug delivery model using Franz cell apparatus for Indomethacin and Tamoxifen. The results showed that BIOCERAMIC enhanced the diffusion and permeability of the drugs. Therefore, we suggest that BIOCERAMIC might enhance the penetration performed by hydrogen bond weakening due to physical induction, and may facilitate local drug delivery in transdermal systems.