Журнал фармацевтической помощи и систем здравоохранения
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Impact of Type of Nebulizers on Liposomes Prepared by Bed Side Reconstitution Technique

Punita Aggarwal, Vaibhavi Patel, Jayrajsinh Sarvaiya

Bedside reconstitution techniques for liposome preparation at the time of drug administration eliminate the stability issue of liquid liposomes products. In this study of Tobramycin sulfate liposomal formulation has been developed as an inhaled therapy for Pseudomonas aeruginosa infection in the lungs. To analyze the effectiveness of Pre and Post drug delivery of liposomal drug formulation, this research article utilizes three types of Nebulizers—Ultrasonic Nebulizers, Mesh Nebulizer, and Compressed Nebulizer. Post nebulization, physicochemical characteristics, and stability of liposomes were evaluated and compared with pre-nebulization characteristics of the liposomes. Ultrasonic nebulization provided better product attributes compared to Mesh and compressed nebulizer based on the analysis performed using Transmission Electron Microscopy, HPLC, Particle size, Zeta Potential, and TCS-PC. The main goal was to determine the entrapment efficacy of the drug in liposomes as well as to determine the liposomal stability and size especially after using the nebulizer as a drug delivery tool to ensure the amount of drug delivered. The statistical data has shown that there is no significant 68 difference in Particle size and entrapment efficacy pre- and post-nebulization using various nebulizers