Журнал клинической токсикологии
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Lipid Peroxidation and Antioxidant Defense System among Workers of the Printing Industry

Shimaa Tarek Ahmed, Fatma Mohamady El Demerdash, Hoda Hassan Baghdadi

Background: The printing industry is one of the largest and most geographically diverse manufacturing industries in the world. In the printing industry, volatile organic compounds main sources of chemical hazards associated with the using of different chemicals and solvents. As a result from environmental and workplace chemical exposures, the toxic chemicals are significant contributors to the human health effects.

Materials and methods: In this prospective study conducted in local printing company with two groups; the control group included (26) male healthy volunteer donors and the second is the workers group included (26) male volunteer workers, who have been exposed to chemicals for long time (10 years). Blood samples were obtained to evaluate oxidative stress biomarker and the antioxidant defense system. Statistical analysis was employed.

Results: When comparing between the two groups; The values of lipid peroxidation biomarker (MDA) and hydrogen peroxide were significantly high, while the levels of enzymatic and non-enzymatic antioxidants were detected with lower significant values (CAT, SOD, GST, GSH) (P<0.05).

Conclusion: Exposure of printing workers chemicals and solvents cause increased oxidative stress.