Журнал наномедицинских и биотерапевтических открытий
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Novel Approach for Designing Supportive Care in Genetic Disorders of Gastrointestinal Tract: Three-Dimensional Polymer Model of Nutritional Therapies in Cystic Fibrosis, Ulcerative Colitis, and Crohn`s Disease

Paul Zarogoulidis, Ioannis Kioumis, Theodora Tsiouda, Nikolaos Pezirkianidis, Christos Ritzoulis, Haidong Huang, Wolfgang Hohenforst-Schmidt, Dionysios Spyratos, Konstantinos Porpodis, Georgia Pitsiou, Sofia Lampaki, John Organtzis, Bianca Kathryn Malecki, Sindre Ervik Saetre, Konstantinos Zarogoulidis and Marek Malecki

Background: Inflammatory diseases such as; crohn`s disease and ulcerative colitis are responsible for the malnutrition of the patients. These patients due to structural damage within the gastrointestinal tract do not absorb nutrients. Cystic fibrosis is a hereditary disease where the viscosity of mucus induces organ deficiency and nutrition malnutrition.

Materials and Methods: A novel polymer tube was constructed in order to evaluate the rheology of different types of nutrients. Results: The current 3D model simulates both light and severe disease with the different types of “traps” that have been constructed within it.

Conclusion: Modification of the different nutrients will elicit the proper future modifications that the industry should make for the patients with these underlying diseases.