Анатомия и физиология: текущие исследования
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Polymorphism Genes Sulfonylurea Receptpr-1 and Potassium InwardlyRectifying Channel Subfamily J Member 11 as a Risk Factor for Type 2 Diabetes Mellitus in Ethnic of Ternate

Muhammad AA,Agussalim A*

Background: Sulfonylurea Receptor-1 (SUR1) and Potassium Inwardly-Rectifying Channel Sub Family J Member 11 (KCNJ11) is the gene at canal its activity of ATP sensitive potassium (KATP). Canal KATP ATP acts as a sensor on the settings of the secretion of insulin. Polymorphism R1273R E23K genes SUR1 and KCNJ11 cause interference with the activity of the Canal KATP, affect the secretion of insulin causing hyperglycemia and Impaired Glucose Tolerance (IGT) are at risk of type 2 DM occurs.

Purpose: Examine the interconnectedness of Polymorphism R1273R E23K genes SUR1 and KCNJ11 as risk factors of type 2 DM on Ternate Ethnic.

Methods: The case-control Design to the subject research of sufferers of type 2 DM (n=52) as Group cases and subject to the Non-DM (n=52) as a control group. Genotyping gene is done by the method of PCR-RFLP. Compare the subject case and control groups with the test t-test are not paired. Test of chi-square and the odds ratio (OR) to analyze the relationship of polymorphism R1273R E23K genes SUR1 and KCNJ11 with risk of incident type 2 DM.

Results: The frequency of Genotype GA genes SUR1 group cases (9.6%) while genotype GA in the control group (3.8%) (p=0.256; Or=2.660). Combination genotype GG genes SUR1 and genotype GA genes KCNJ11 compared to genotype GG genes SUR1 and KCNJ11 is a protective factor for DM (p=0.000; Or=0.083). Genotype GG genes SUR1 and AA genotype genes KCNJ11 compared to genotype GG genes SUR1 and KCNJ11 (p=0.975; Or=1.031).

Conclusion: The individual carrier genotype GA polymorphism R1273R genes SUR1 statistically not different but has a significant risk of developing type 2 DM. Genotype GA E23K genes KCNJ11 polymorphism as protective factors in type 2 DM on Ternate ethnic.