Биохимия и фармакология: открытый доступ
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Protective Effects of Cyclohexyl methyl dithiocarbamates Sodium Salts on Diclofenac Induced Reproductive Toxicity in Male Albino Rats

Adegbegi J Ademuyiwa, Jose R Adeolu and Adefegha S Adeniyi

The present study investigates the effect of cyclohexylmethyldithiocarbamates sodium salt (a synthetic compound) and vitamin E against diclofenac-induced blood and testes of experimental Wistar male albino rats. The study consists of six groups of six rats each. Group I (control) received corn oil (3 ml/kg b.w), Group II received diclofenac (100 mg/kg b.w), Group III rats were treated with diclofenac and cyclohexylmethyldithiocarbamates sodium salt (30 mg/kg b.w), Group IV was administered diclofenac and Vitamin E (30 mg/kg b.w), Group V was given cyclohexylmethyldithiocarbamates sodium salt (30 mg/kg b.w) only and Group VI received vitamin E only. The results showed a significant (p<0.05) decrease in the daily sperm production in the diclofenac only treated rats, diclofenac with Na (HxMedtc), diclofenac with vitamin E treated rats and Na (HxMedtc) treated rats but no significant (p>0.05) in the vitamin E only treated rats when compared with the control. There was a significant (p<0.05) decrease in the Testicular sperm number (TSN) in the diclofenac only treated rats, diclofenac with Vitamin E treated rats and vitamin E only treated rats and no significant (p>0.05) decrease in the diclofenac with Na (HxMedtc) treated rats and Na (HxMedtc) only treated rats when compared with the control. Also, there was a significant (p<0.05) decrease in TSN in the diclofenac with Na (HxMedtc) treated rats and diclofenac with vitamin E treated rats when compared with diclofenac only treated rats. And a decrease (p<0.05) in the daily sperm production (DSP) in the diclofenac only treated rats, and diclofenac with cyclohexylmethyldithiocarbamate sodium salt only treated rats when compared with the control.