Журнал клинической и клеточной иммунологии
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Puzzling presentation of inborn errors of immunity (IEIs) with predominant neuropsychiatric symptoms – experience in the pediatric allergy/immunology clinic

Harumi Jyonouchi*

Due to close interactions between the nervous system and the immune system, patients with Inborn Errors of Immunity (IEIs) can present clinical features of common neuropsychiatric and neurodevelopmental conditions. These include high anxiety, mood swing, developmental issues and dysautonomic symptoms, consistent with Postural Orthostatic Tachycardia Syndrome (POTS). These neuropsychiatric symptoms may be predominant clinical features in certain cases, making it further confusing for practicing physicians for diagnosing IEIs. This mini review focuses on the importance of these puzzling neuropsychiatric symptoms in patients with IEIs, by presenting clinical cases experienced in our clinic.