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Reduced Accumulation of the Prion Pathogenic Protein (PrPsc) in Mice Spleen Post Inoculation with a Mixture of the Scrapie C506M3 Strain and Streptomycin

Aly Moussa

The hydrogen bond transfer between the two guanidine groups present on streptomycin and the different amino acids on the PrPsc peptides provoked changes of the surface electric charges and even probably affected the stability and induced a drop in the PrPsc infectivity. These can explain the reduction to even absence of accumulated prion infectivity marker PrPsc observed at 45 days post intraperitonial inoculation of a mixture of streptomycin and infected mouse brain homogenate of the scrapie strain C506M3 compared to controls.