Международный журнал физической медицины и реабилитации
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Controversial Aspects of Static Respiratory Compliance and D-Dimer in COVID-19 Associated ARDS

Chiara Mega*, Tommaso Tonetti, Alessio Dell’Olio, Marco Vito Ranieri

Clinical outcomes in COVID-19 associated acute respiratory distress syndrome may be influenced by respiratory system mechanics, CT scan findings, oxygenation variables and biomarkers. Low respiratory system compliance and high plasmatic D-dimer were associated to higher mortality rate in a subgroup of COVID-19 patients. Our purpose is to review the impact of respiratory compliance and plasmatic D-dimer in COVID-19 associated acute respiratory distress syndrome according to recent literature. Increased D-dimer concentration in COVID-19 patients is a strong predictor of worse outcome while static respiratory compliance is not. Combined evaluation of both enhances the prediction of mortality in COVID-19 related ARDS.