Журнал остеопороза и физической активности
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Efficacy of Zoledronic Acid Treatment in Paget Disease of Bone

Emine Kartal Baykan, Sevki Cetinkalp, Gokhan Ozgen and Candeger Yilmaz

Purpose: Paget disease is a disease of bone of unknown etiology with increased bone turnover that results in defective bone microarchitecture and bone deformity. Bisphosphonates are used in symptomatic Paget disease of bone. Clinical trials have shown that zoledronic acid was more effective than other bisphosphonates in treatment of Paget disease.

Methods: In this study, we retrospectively reviewed the remission and relapse statuses of 12 patients with Paget disease of bone, who were seen as outpatients between October 2011 and October 2013. We evaluated alkaline phosphates, osteocalcin, deoxypyridinoline levels measured before and at 6^th, 12^th, 18^th months of treatment.

Results: Pretreatment values for alkaline phosphates, deoxypyridinoline, osteocalcin were as follows; 473 ± 256 U/L, 14.99 ± 7.63 mmol/L, 21.09 ± 3.18 ng/ml and post-treatmen valus for alkaline phosphates, deoxypyridinoline, osteocalcin were as follows; 82 ± 13 U/L, 5.14 ± 1.11 mmol/L, 8.57 ± 4.31 ng/ml. Remission was achieved in all patients after treatment. The levels indicated remission continued at 12^th and 18^th months of treatment. There was statistically significant difference between pretreatment and post-treatment values. No statistically significant difference between the levels measured at 6^th, 12^th and 18^th months of treatment was detected.

Conclusion: We recommend zoledronic acid in the first line treatment of Paget disease of bone in achieving and maintaining remission.