Ревматология: текущие исследования
Открытый доступ

Абстрактный

Henoch Schonlein Purpura in Children Ages 2-18 in Poria Hospital: Clinical Manifestations of 100 Cases Over a 12 year Period

Sleman B, Berkovich A, Nasser S, Boshra N, Haia N, Nasser W

Background: Henoch-Schönlein Purpura (HSP) is the most common childhood vasculitis. It is a systemic vasculitis with multiorgan involvement. Diagnosis is based on clinical criteria. The classic tetrad of signs and symptoms includes palpable purpura, arthritis or arthralgia, abdominal pain and renal disease. Other organs involvement such as brain, lungs, and scrotum are less common but may be occasionally involved.

Methods: Retrospective study of 100 patients that were hospitialized and diagnosed with HSP between 2006-2018 in Poria hospital included in the research. Patients were chosen based on EULAR criteria.

Results: 100 patients entered the study, with male predominance (M:F ratio of 1.17). The average age was 6.3 and the median age 6. 88% of patients were under the age of 10 when diagnosed. Average length of stay in the hospital was 2 days. Most of the patients presented in the winter and spring month (October-March). The most frequent laboratory abnormality was leucocytosis (30%), and 2% of patients had proteinuria, but none had renal injury. Clinically, all of the patients had palpable purpua (a mandatory criteria according to the EULAR), 67% had joint involvement, 32% had abdominal pain and 11% of boys had testicular pain. A statistically significant correlation was demonstrated between joint pain and increase signs of inflammation, between anemia and fever and between abdominal pain and chances of future relapses. Not a single patient developed acute or chronic renal failure.

Conclusions: The epidemiological, laboratory and clinical presentation in this study were not different from what described in the literature and other similar studies around the globe. We did found a statistically significant correlation between presentation of abdominal pain to relapses of the disease in the future. Not a single patient developed acute or chronic renal failure.