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Trans-Sex: Time to Give Up Old Concepts

Shimaa M. Motawei*, Adel M. Elmansoury

Background: Trans-sexualism is a disorder when an individual feels inconsistent with his/her assigned sex, and desires for a permanent transition to the opposite sex. It has for long been considered a whim of a disturbed mind. However, it may be a true biological disturbance that needs correction earlier better than later in the age of the person who shows the desire of transition to the opposite sex. Objectives: To highlight the issue of trans-sex, its incidence and prevalence, and its biological causes, to remove the confusion and the many wrong concepts about this medical problem. Methods: A comprehensive systematic search for the data, in the search engines using the key words, using a repeatable method; appraising the data (and the quality of the data) with filtration to exclude duplication and a synthesis of research data. Trans-sex individuals exhibit persistent and authentic differences from the cis-sex individuals. The early decision is better because of the psychological, social and job consequences of sex in the life of the person. Societies’ intolerance to trans-sex persons may be very challenging and can cause anxiety disorders, depression, and other psychologic disturbances. Conclusion: Trans-sex is a true biological disorder that needs proper diagnosis and management. Reaching a diagnosis in cases of trans-sex requires physicians to be oriented of the rare, but an existing, biological disturbance and how to approach for reaching a diagnosis of trans-sexualism. HY-antigen typing, brain imaging for the anatomical differences between male and female brains, and other investigations that are useful in such cases and are discussed in this review.